Immortalized intestinal epithelial cell lines
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United States of America Patent
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Sep 22, 1998
Issued Date -
N/A
app pub date -
Nov 18, 1994
filing date -
Jul 12, 1993
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Expired
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Abstract
Novel intestinal epithelial cell lines having stably incorporated heterologous DNA having a temperature-sensitive mutant oncogene are described, wherein the cell line proliferates at permissive temperatures in a conditionally immortalizing phenotype; and ceases to proliferate at nonpermissive temperatures thereby effecting cessation of cell proliferation and a differentiated intestinal epithelial cell phenotype including expression of certain brush border enzymes, and keratin markers.
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