Dry powder formulations of polynucleotide complexes
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United States of America Patent
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Sep 22, 1998
Issued Date -
N/A
app pub date -
Jun 9, 1995
filing date -
Jun 7, 1995
priority date (Note) -
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Abstract
Polynucleotide complexes are stabilized by adding a cryoprotectant compound and lyophilizing the resulting formulation. The lyophilized formulations are milled or sieved into a dry powder formulation which may be used to deliver the polynucleotide complex. Delivery of the polynucleotide to a desired cell tissue is accomplished by contacting the tissue with the powder to rehydrate it. In a preferred embodiment, a dry powder formulation is used to transfer genetic information to the cells of the respiratory tract.
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