Transdermal delivery of encapsulated drugs
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United States of America Patent
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Sep 29, 1998
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N/A
app pub date -
Aug 4, 1995
filing date -
Aug 4, 1995
priority date (Note) -
Expired
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Abstract
Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-molecular weight proteins. This method includes a simultaneous application of ultrasound and protein on the skin surface in order to deliver therapeutic doses of proteins across the skin. Examples demonstrate in vitro and in vivo administration of insulin (molecular weight 6,000 D), and in vitro administration of gamma interferon (molecular weight 17,000 D), and erythropoeitin (molecular weight 48,000 D).
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