S-fluoro-anthracyclines, processes for their preparation and pharmaceutical compositions containing them
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United States of America Patent
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Sep 29, 1998
Grant Date -
N/A
app pub date -
Apr 21, 1997
filing date -
Aug 4, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
8-fluoro-anthracyclines of formula (I) have anti-tumor activity. ##STR1## wherein: R is chosen in the group consisting of H, OH, OR.sub.4 wherein R.sub.4 is chosen in the group consisting of CHO, COCH.sub.3, acyl derivative of a carboxylic acid containing up to 6 carbon atoms; R.sub.1 is chosen in the group consisting of: H, OH, OCH.sub.3 ; R.sub.2 is chosen in the group consisting of: H, OH, NH.sub.2 R.sub.3 is chosen in the group consisting of: H, OH, NH.sub.2, residue of formula (A) ##STR2## The compounds are characterized by having cis-stereochemistry between the groups 8--F and 9--OH. Their preparation and pharmaceutical compositions containing them are also described.
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