Methods of preventing tissue damage associated with decreased blood flow by administration of AICA riboside compounds

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United States of America Patent

PATENT NO 5817640
SERIAL NO

08443245

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Abstract

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Methods of preventing tissue damage associated with decreased blood flow in a human by administering AICA riboside or a prodrug thereof in an amount which provides a blood plasma concentration of between 1 .mu.g/ml and 20 .mu.g/ml of AICA riboside for a time sufficient to reduce the risk of said tissue damage in said human. Methods of preventing an adverse clinical outcome, such as an adverse cardiovascular and/or cerebrovascular event, in a patient at risk for such outcome by administering AICA riboside or a prodrug thereof in an amount which provides a blood plasma concentration of between 1 .mu.g/ml and 20 .mu.g/ml of AICA riboside for a time sufficient to reduce the risk for said patient.

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Patent Owner(s)

Patent OwnerAddress
METABASIS THERAPEUTICS INC3911 SORRENTO VALLEY BOULEVARD SUITE 110 SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gruber, Harry E Rancho Santa Fe, CA 66 879
Laikind, Paul K San Diego, CA 11 216
Mullane, Kevin M Del Mar, CA 4 53

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