Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease
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United States of America Patent
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Oct 13, 1998
Issued Date -
N/A
app pub date -
Feb 4, 1997
filing date -
Jan 29, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method of treating patients suffering from a respiratory disease using a programmable, hand-held, self-contained drug dispensing device is disclosed. A patient's inspiratory flow rate is measured and a determination is made of a typical and preferred rate and volume for the release of respiratory drug. To obtain repeatability in dosing the drug is repeatedly released at the same rate and volume. To maximize the amount of drug delivered based on the amount released the drug is released at a rate of from about 0.10 to about 2.0 liters/second and (2) a volume of about 0.15 to about 0.8 liters. Parameters such as rate, volume, and particle size of the aerosolized formulation are adjusted to obtain repeatable dosing of the maximum amount of drug to the desired area of the lung. Lung function is measured and use parameters are adjusted in order to improve lung function.
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