Gas-filled amino acid block co-polymer microspheres useful as ultrasound contrast agents

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United States of America Patent

PATENT NO 5820850
SERIAL NO

08486770

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Abstract

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The present invention relates to gas-filled microspheres useful as ultrasound contrast agents. More particularly, the present invention relates to gas-filled microspheres prepared from amphiphilic poly amino acid block co-polymers and a pharmacologically acceptable water-insoluble gas. The hydrophobic block of the co-polymer is formed from amino acids possessing hydrophobic side-chains, for example, leucine, isoleucine, valine, and phenylalanine, and the hydrophilic block of the co-polymer is formed from amino acids possessing hydrophilic side-chains, for example, glutamic acid (and its ionized form, glutamate), aspartic acid (and its ionized form, aspartate), and lysine.

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Patent Owner(s)

Patent OwnerAddress
MOLECULAR BIOSYSTEMS INC10030 BARNES CANYON ROAD SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hashimoto, Yukio Washington, DC 63 518
Lohrmann, Rolf La Jolla, CA 17 544

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