Importance

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Abstract

A percutaneous or permucosal patch drug preparation. The preparation includes: (1) a backing layer impermeable to a drug component, (2) a drug storage layer which holds the drug component therein and is situated under the central portion of the backing layer, (3) a protective film which is impermeable to the drug component, has notches and is situated under the drug storage layer and the peripheral portion of the backing layer, (4) a pressure-sensitive adhesive layer which is situated under the protective film, and (5) a releasable liner layer which is impermeable to the drug component and situated under the pressure-sensitive layer. When the releasable liner layer is peeled off of the preparation, the protective film is torn along the notches and the portion of the protective film surrounded by the notches is removed together with the releasable liner layer and a portion of the adhesive between the protective film and the releasable liner layer. The patch drug preparation is held on the skin or mucosa of a patient by the pressure-sensitive adhesive remaining on the peripheral portion of the protective film. The drug held in the drug storage layer is released directly to the mucosa or to the skin.

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First Claim