Control of the synthesis of proteins by anitisense RNA-tRNA complex
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United States of America Patent
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Oct 13, 1998
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app pub date -
Nov 28, 1994
filing date -
Apr 16, 1992
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Abstract
The inhibition of proteins synthesis by an antisense RNA-tRNA complex which is capable of inhibiting translation is described. Under certain conditions, growth of organisms is inhibited by inhibition of non-specific translation by an antisense RNA construct to a tRNA target. In vitro, cell-free inhibition of viral protein translation is described. Transformed microorganisms are disclosed. The invention has applicability in the control of cell growth, such as viruses, bacteria, infected cells, or tumor cells. The invention is useful in animal and plant fields.
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