Combinatorial dihydrobenzopyran library
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United States of America Patent
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Oct 13, 1998
Issued Date -
N/A
app pub date -
Nov 3, 1995
filing date -
May 6, 1994
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Expired
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Abstract
Combinatorial libraries are disclosed which are represented by Formula I: (T'--L).sub.q --S--C(O)--L'--II' I wherein: S is a solid support; T'--L-- is an identifier residue; and --L'--II' is a ligand/linker residue. These libraries contain dihydrobenzopyrans of the formula: ##STR1## which interact (i.e., as agonists or antagonists) with .alpha. adrenergic receptors, dopamine receptors, .sigma.-opiate receptors, and K.sup.+ channels and are inhibitors of carbonic anhydrase isozymes. They are useful in the treatment of ocular diseases such as glaucoma.
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