Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
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United States of America Patent
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Oct 13, 1998
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app pub date -
Jun 7, 1995
filing date -
Jul 14, 1992
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Abstract
Synthetic polypeptide analogs of parathyroid hormone PTH, parathyroid hormone related peptide PTHrp, and of the physiologically active truncated homologs and analogs of PTH and PTHrp, in which amino acid residues (22-31) form an amphipathic .alpha.-helix, said residues (22-31) selected from hydrophilic amino acids (Haa) and lipophilic amino acids (Laa) ordered in the sequence: Haa(Laa Laa Haa Haa).sub.2 Laa and their pharmaceutically acceptable salts are useful for the prophylaxis and treatment of corticosteroid induced osteopenia in mammals.
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