Method for non-invasive blood analyte measurement with improved optical interface
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United States of America Patent
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Oct 20, 1998
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N/A
app pub date -
Apr 18, 1997
filing date -
Aug 9, 1995
priority date (Note) -
Expired
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Abstract
A method for non-invasively measuring the concentration of an analyte, particularly blood analyte in blood. The method utilizes spectrographic techniques in conjunction with an improved optical interface between a sensor probe and a skin surface or tissue surface of the body containing the blood to be analyzed. An index-matching medium is disclosed to improve the interface between the sensor probe and skin surface during spectrographic analysis. In a preferred embodiment, the blood analyte concentration in blood is quantified utilizing a partial squares analysis relative to a model incorporating analysis of plural known blood samples.
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