Conformationally-restricted combinatiorial library composition and method
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United States of America Patent
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Oct 20, 1998
Issued Date -
N/A
app pub date -
Jun 16, 1995
filing date -
May 18, 1994
priority date (Note) -
Expired
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Abstract
Combinatorial libraries of different-sequence peptide members is disclosed. The libraries are comprised of stabilized, alpha-helical polypeptides having a similar tertiary structure but different amino acid residues at specific, 'variable' positions in the sequence. The polypeptides are stabilized through coiled-coil interactions with other .alpha.-helical polypeptides and/or via intrahelical lactam bridges. Also disclosed are methods for using such libraries to screen for selected macromolecular ligands.
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