Phage-display of immunoglobulin heavy chain libraries for identification of inhibitors of intracellular constituents
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United States of America Patent
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Oct 20, 1998
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Jul 19, 1997
filing date -
May 9, 1995
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Abstract
One aspect of the invention relates to a phage-display library that expresses single-chain recombinant binding proteins. Inserts in the library comprise immunoglobulin heavy chain framework regions flanking highly divergent, synthetically produced hypervariable regions. A second aspect of the invention relates to the use of single-chain recombinant binding proteins to inhibit the activity of an intracellular constituent. In the exemplary case presented, the activity of intracellular glucose-6-phosphate dehydrogenase was inhibited by intracellular expression of a cloned single-chain recombinant binding protein.
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