Process for modification of implant surface with bioactive conjugates for improved integration
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United States of America Patent
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Oct 20, 1998
Issued Date -
N/A
app pub date -
Jun 28, 1996
filing date -
May 10, 1993
priority date (Note) -
Expired
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Abstract
The present invention relates to a process for the covalent coating of implants with a bioactive conjugate, which comprises the steps of: a) cleaning a metal implant surface from contaminants by deoxidation with potentiostatic electrochemical polishing in a solution selected from ethanol, perchloric acid-butanol-methanol solution, H.sub.2 O.sub.2 --NaCl--NaH.sub.2 PO.sub.4 or by chemical cleaning with a solution selected from the group consisting of HF/HNO.sub.3, H.sub.2 O.sub.2 /H.sub.2 SO.sub.4 and H.sub.2 O.sub.2 /KOH; b) coating the cleaned implant surface of step a) with a bioactive conjugate, wherein the conjugate has the following structural Formula I: --R--X--P I wherein, R is O or S, adapted to be covalently attached to an implant surface; X is selected from a bond, linear or branched chains of 1 to 30 covalently attached atoms of at least C, N, O, Si or S, rings of 1 to 20 covalently attached atoms of at least C, N, O, Si or S, and a combination thereof; and P is a bioactive molecule moiety which promotes tissue growth, stabilization and integration, and wherein the moiety retains its biological activity.
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