Heterocyclic acyldipeptides, processes for the preparation thereof and pharmaceutical compositions containing the same
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United States of America Patent
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Oct 20, 1998
Grant Date -
N/A
app pub date -
Jan 4, 1996
filing date -
Apr 22, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Heterocyclic acyldipeptides of the formula I ##STR1## wherein Z represents an oxygen or sulphur atom or a --CH.sub.2 -group; R.sub.1, R.sub.2 and R.sub.3 individually represent hydrogen or certain organic groups; R.sub.4 and R.sub.5, which are identical or different, represent an OR.sub.6 or NHR.sub.6 group, wherein R.sub.6 is hydrogen or certain organic groups; Y represents a --CH.sub.2 --, .dbd.CH-- or .dbd.N-- group; A represents a --(CH.sub.2).sub.3 -- group when Y is --CH.sub.2 --, the two rings being transcondensed, or a ##STR2## wherein R.sub.7 represents H, F, Br, Cl, nitro, or certain organic groups when Y is .dbd.CH-- or .dbd.N--; and their pharmaceutically acceptable salts are provided. These heterocyclic acyldipeptides and their salts are useful as active compounds in medicaments having immunostimulatory and antitumor activity.
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