Human stromelysin-1 promoter
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United States of America Patent
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Oct 20, 1998
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app pub date -
Dec 23, 1994
filing date -
Dec 23, 1994
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Abstract
This invention relates to a human stromelysin-1 (i.e., HSL-1) promoter and uses therefor. In particular, the invention provides a purified DNA containing a functional HSL-1 promoter region that corresponds in structure to the native genomic form of this promoter, an expression vector containing a portion of the purified promoter DNA operatively linked to a heterologous DNA sequence encoding a detectable gene product, a host cell transformed with this factor , a pharmacologic screening assay for stromelysin-1 promoter modulating activity, and a method of modulating TNF .alpha. level and matrix metalloproteinase activities in inflamed tissues of a mammal.
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