Method and apparatus for determining analytical data concerning the inside of a scattering matrix

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United States of America Patent

PATENT NO 5825488
SERIAL NO

08745204

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Abstract

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A method and an apparatus for determining analytical data concerning the inside of a scattering matrix, in particular of a biological sample. In a detection step detection measurements are carried out in which light is irradiated into the matrix as primary light at an irradiation site (12) through an interface bounding the scattering matrix (6) and light emerging out of the scattering matrix through the interface is detected as secondary light at a detection site (13) at a predetermined measuring distance from the irradiation site, in order to determine as a measurement variable a measurable physical property of the light which varies due to the interaction of the light with the scattering matrix, which measurement variable is a measure of the analytical data to be determined. In an evaluation step the analytical data are determined on the basis of the measurement variable measured in the detection step. In order that such a matrix analysis may be carried out with relatively simple measuring means, at least two detection measurements are carried out in the detection step with different reflection conditions at the interface (5) between the irradiation site (12) and the detection site (13), in each of which the measurement value of the measurement variable is determined.

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Patent Owner(s)

Patent OwnerAddress
BOEHRINGER MANNHEIM GMBHTHE FEDERAL REPUBLIC OF GERMANY MANNHEIM MANNHEIM BADEN-WURTTEMBERG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boecker, Dirk Heidelberg, DE 140 24688
Cope, Mark Avon, GB3 18 525
Essenpreis, Matthias Gauting, DE 30 4184
Kohl, Matthias London, GB3 17 333

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