Contiguous genomic sequence scanning

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United States of America Patent

PATENT NO 5830665
SERIAL NO

08808763

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Disclosed are methods for the detection of loss of genomic integrity characteristic of genomic instability. The methods are especially useful for detection of deletions of genomic DNA that occur in early stages of Cancer, especially colorectal cancer. Methods of the invention involve the detection in a biological sample of a nucleic acid fragment which includes both 3' and 5' DNA sequence which normally flank a region where a deletion is suspected. The assay is designed as disclosed herein such that there is only a small or negligible likelihood that the fragment will be present unless a deletion has occurred.

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Patent Owner(s)

Patent OwnerAddress
ESOTERIX GENETIC LABORATORIES LLC358 SOUTH MAIN STREET BURLINGTON NC 27215 UNITED STATES OF AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Shuber, Anthony P Milford, MA 154 5026
Waller, Patrick R H Wellesley, MA 1 53

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