Triazole substituted quinoline derivatives for gastrointestinal treat-treatment
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United States of America Patent
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Nov 3, 1998
Grant Date -
N/A
app pub date -
Jan 29, 1996
filing date -
Apr 1, 1993
priority date (Note) -
Expired
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Abstract
The invention relates to pharmaceutical compositions for the treatment or prevention of lesions of gastrointestinal mucous membranes and having secretion inhibiting, cytoprotective activities. The compositions contain in a biologically effective quantity a triazole-group-substituted quinoline derivative of general formula (I) R.sup.1 stands for a 1-triazolyl-group in position 2 or 4 or a 3-triazolyl-thio or a 5-/C.sub.1-4 -alkyl/-3-triazolyl-thio-group, R.sup.2 stands for a hydrogen atom in position 3 or optionally in position 2, or for a C.sub.1-4 -alkyl-group, R.sup.3 stands for a hydrogen atom or for a C.sub.1-4 -alkyl-group, X stands for a hydrogen or halogen-atom or for a C.sub.1-4 -alkyl-group or its salts. The invention includes processes for the preparation of the above compositions, and methods for treatment of patients in need of such treatment by administering the substance or the composition. The prefered substance of formula (IV) is also subject of the invention.
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