Compositions and methods for modulating .beta.-amyloid
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United States of America Patent
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Nov 17, 1998
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app pub date -
Oct 28, 1994
filing date -
Dec 24, 1991
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Abstract
Compositions and methods are provided for the modulation of abnormal expression of .beta.-amyloid. Oligonucleotides are provided which are specifically hybridizable with RNA or DNA encoding .beta.-amyloid. Oligonucleotides specifically hybridizable with a translation initiation site, codon 717, codon 670 or codon 671 of .beta.APP are provided. Such oligonucleotides can be used for diagnostics as well as for research purposes. Methods are also disclosed for modulating .beta.-amyloid expression in cells and tissues using the oligonucleotides provided, and for specific modulation of expression of the mutant .beta.APP gene. Methods for diagnosis, detection and treatment of diseases associated with abnormal .beta.APP expression are also disclosed.
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