Phenotypic characterization of the hematopoietic stem cell

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United States of America Patent

PATENT NO 5840580
SERIAL NO

08856406

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Abstract

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One or more population of cells enriched for human hematopoietic stem cells is disclosed. HSC in this population of cells are capable of limited self-renewal and are capable of differentiating into all elements of the hematopoietic system. This population of cells has the phenotype of CD34.sup.+ /CD38.sup.- and more preferably CD34.sup.+ /CD38.sup.-/HLA-DR.sup.+. Cells within this population have been found to express CD13, CD33 and CD71. Hematopoietic stem cells can be used in a number of therapies, including autologous transplantation and in gene therapy.

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Patent Owner(s)

Patent OwnerAddress
BECTON DICKINSON AND COMPANYFRANKLIN LAKES NEW JERSEY 07417-1880

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Huang, Shiang San Ramon, CA 1 78
Loken, Michael R Mercer Island, WA 17 550
Lund-Johansen, Fridtjof Fremont, CA 10 123
Olweus, Johanna Fremont, CA 7 121
Terstappen, Leon W Huntingdon Valley, PA 1 78

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