Purification of hemoglobin
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United States of America Patent
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Nov 24, 1998
Issued Date -
N/A
app pub date -
May 10, 1995
filing date -
Jul 23, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention generally relates to methods for purifying hemoglobin solutions and to hemoglobin solutions obtained by the methods. In one aspect, such methods include removing contaminants in crude hemoglobin-containing lysates with heat treatment. In a further aspect, the present invention provides methods for producing substantially purified hemoglobin solutions using immobilized metal affinity chromatography, optionally following by anion exchange chromatography.
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