Redox and photoinitiator priming for improved adherence of gels to substrates

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United States of America Patent

PATENT NO 5844016
SERIAL NO

08478104

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Importance

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Abstract

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An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. The barrier can be prepared by staining tissue with a photoinitiator, applying a solution containing a polymerizable barrier material solution and a photoinitiator to the tissue, and polymerizing the polymer solution on exposure to light. The resulting polymer adheres strongly to the tissue surface, and also forms a gel in the rest of the applied volume. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. The method can be used to adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. Tissue surfaces can be adhered to each other to repair wounds. In addition to photochemical initiators, non-photochemical initiators and combinations of chemical initiators and photochemical initiators can be used.

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Patent Owner(s)

Patent OwnerAddress
GENZYME CORPORATION450 WATER STREET CAMBRIDGE MA 02141

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Avila, Luis Z Arlington, MA 41 1905
Barman, Shikha P Lowell, MA 41 1542
Coury, Arthur J Boston, MA 59 4551
Goodrich, Stephen D Woburn, MA 27 1238
Hubbell, Jeffrey A San Marino, CA 173 9467
Kieras, Mark T Newburyport, MA 11 928
Melanson, David A Hudson, NH 74 8220
Pathak, Chandrashekar P Lexington, MA 3 378
Rudowsky, Ronald S Sudbury, MA 12 1714
Sawhney, Amarpreet S Lexington, MA 147 16056
Weaver, Douglas J K Bedford, MA 4 403

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