Synthetic triple helix-forming compound precursors
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United States of America Patent
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Dec 1, 1998
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N/A
app pub date -
Feb 1, 1995
filing date -
Feb 1, 1995
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Expired
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Abstract
The present invention discloses novel monomeric compositions which are substituted quinoline- or quinazoline-based structures capable of hydrogen bonding specifically with interstrand purine-pyrimidine base pairs in a double-stranded Watson-Crick DNA molecule. Furthermore, the novel monomeric compounds of the present invention are capable of being assembled in specific sequences into oligomers capable of binding with sequence specificity to duplex DNA via a triple helix motif.
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