Pharmaceutical formulation
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United States of America Patent
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Dec 15, 1998
Issued Date -
N/A
app pub date -
Jun 2, 1995
filing date -
Dec 20, 1991
priority date (Note) -
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Abstract
A pharmaceutical preparation comprising a growth hormone and histidine or a derivative of histidine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved preparation at ambient temperature. Crystallization of growth hormone in the presence of histidine or a derivative thereof gives rise to a higher yield of crystals having a higher purity than known methods.
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