US Patent No: 5,849,761
Number of patents in Portfolio can not be more than 2000
Peripherally active anti-hyperalgesic opiates
Stats
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Dec 15, 1998
Issued date -
Sep 12, 1995
filing date -
08/528,510
serial no -
In Force
status
Importance
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Abstract
Methods using compositions for the treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors, but that do not, upon topical or local administration, elicit central nervous system side effects. The anti-diarrheal compound 4-(p-chlorophenyl)-4-hydroxy-N-N-dimethyl-.alpha.,.alpha.-diphenyl-1-piperidinebutyramide hydrochloride is preferred for use in the compositions of the claimed methods.
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First Claim
Related Publications
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International Classification(s)
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Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
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| 4,194,045 1-(3,3-Diaryl-3-oxadiazolalkyl)-4-phenyl-4-piperidinomethanols and related compounds | 17 | 1977 | |
| 4,533,739 2-[(Aminophenyl and amidophenyl)amino]-1-azacycloalkanes having antidiarrheal activity | 30 | 1982 | |
| 5,354,863 Opioid agonist compounds | 35 | 1993 | |
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| 4,824,853 .alpha.,.alpha.-diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, N-oxides and method of treating diarrhea | 15 | 1986 | |
| 4,898,873 .alpha.,.alpha.-Diaryl-4-aryl-4-hydroxyl-1-piperidinebutanamide, N-oxides and pharmaceutical use | 7 | 1989 | |
| 4,990,521 4-(aroylamino)piperidine-butanimide derivatives | 15 | 1989 | |
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| 4,203,920 Amidinoureas | 21 | 1978 | |
| 4,326,074 Amidinoureas | 17 | 1979 | |
| 4,326,075 Amidinoureas | 16 | 1980 | |
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| 5,646,151 Kappa agonist compounds and pharmaceutical formulations thereof | 49 | 1996 | |
| 5,667,773 Film-forming compositions of antihyperalgesic opiates and method of treating hyperalgesic conditions therewith | 27 | 1996 | |
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| 5,460,821 Molecular transdermal transport system | 20 | 1994 | |
| 5,645,854 Molecular transdermal transport system | 18 | 1995 | |
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| 4,371,463 Enzyme-resistant opiate pentapeptides | 14 | 1977 | |
| 5,345,943 Apparatus for determining in vivo response to thermal stimulation in an unrestrained subject | 14 | 1992 | |
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| 4,749,706 Orally active nonaddicting analgesics | 10 | 1986 | |
| 5,366,979 Orally active nonaddicting analgesics | 10 | 1990 | |
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| 5,300,648 Dialkylenepiperidino compounds and their enantiomers, process for preparing them and pharmaceutical compositions containing them | 17 | 1992 | |
| 5,446,052 Dialkylenepiperidino compounds and their enantiomers, process for preparing them and pharmaceutical compositions containing them | 11 | 1994 | |
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| 4,218,454 N-.alpha.Methylcyclopropylmethyl derivatives of normorphine and noroodeine, and analgesic compositions and methods employing the normorphine derivatives | 10 | 1978 | |
| 4,269,843 N-Sec-alkyl analogs of norcodeine and normorphine and analgesic compositions and methods employing the normorphine derivatives | 9 | 1980 | |
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| 5,116,868 Effective ophthalmic irrigation solution | 46 | 1989 | |
| 5,432,176 Method of retarding the progression of chronic renal failure | 14 | 1992 | |
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| 4,493,848 Compositions and methods useful for producing analgesia | 44 | 1983 | |
| 5,116,847 Use of loperamide and related compounds for treatment of respiratory disease symptoms | 17 | 1991 | |
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| 5,273,056 Use of combinations of viscoelastics during surgery | 22 | 1992 | |
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| 5,112,596 Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability | 52 | 1990 | |
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| 5,286,751 Sustained/enhanced antipyretic response | 9 | 1990 | |
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| 5,312,899 Dermorphin analogs | 34 | 1989 | |
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| 4,416,886 Method of treating pruritis and composition therefor | 20 | 1981 | |
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| 2002/0161,403 Deep brain stimulation system for the treatment of parkinson's disease or other disorders | 2001 | ||
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| 4,277,605 Chemical compounds | 17 | 1980 | |
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| 4,626,539 Trandermal delivery of opioids | 65 | 1985 | |
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| 4,871,750 Use of dioxopiperidine derivatives as analgesics | 14 | 1988 | |
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| 4,407,794 Peptides and therapeutic applications thereof | 11 | 1981 | |
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| 5,436,009 Sustained release suppositories and a process for preparation | 11 | 1992 | |
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| 5,214,080 Process for producing nonaqueous dispersion-type resin | 11 | 1991 | |
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| 4,917,896 Penetration enhancers for transdermal delivery of systemic agents | 19 | 1986 | |
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| 4,939,142 Substituted styrene derivatives | 8 | 1989 | |
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| 5,589,480 Topical application of opioid analgesic drugs such as morphine | 18 | 1994 | |
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| 4,430,327 Method for treating pregnant females for pain and anxiety | 12 | 1982 | |
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| 5,384,124 Solid porous unitary form comprising micro-particles and/or nano-particles, and its preparation | 84 | 1992 | |
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| 5,387,688 Intermediates for making analgesic N-phenyl-N-(3-OR.sup.1 -3-Me-4-piperidinyl)amides | 7 | 1992 | |
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| 5,434,292 Phenylalkanoic acid derivatives, process for producing the same and process for separating optical isomers thereof | 15 | 1994 | |
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| 4,238,390 Synthesis and biological activity of [D-Thr.sup.2, .DELTA..sup.3 Pro.sup.5 ]-enkephalinamide | 7 | 1979 | |
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| 4,892,735 Platinum chemotherapeutic product | 14 | 1989 | |
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| 5,236,947 Propanamines, their pharmacological properties and their application as an antidiarrheal | 17 | 1992 | |
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| 5,143,938 Propanamines, their pharmacological properties and their application for therapeutic in particular antidiarrheal, purposes | 8 | 1991 | |
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| 5,242,944 Phenylacetamide derivatives and pharmaceutical compositions thereof | 23 | 1992 | |
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| 4,517,295 Hyaluronic acid from bacterial culture | 96 | 1983 | |
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| 5,248,505 Method for treating gastrointestinal distress | 15 | 1992 | |
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| 5,240,932 Percutaneously absorbable compositions of morphine or analogous analgesics of morphine | 25 | 1992 | |
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| 5,446,070 Compositions and methods for topical administration of pharmaceutically active agents | 157 | 1993 | |
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| 5,100,903 N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds | 8 | 1990 | |
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| 5,478,814 Hemorrhoidal, other compositions and methods of treatment | 15 | 1993 | |
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| 4,328,803 Ophthalmological procedures | 60 | 1980 | |
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| 5,069,909 Transdermal administration of buprenorphine | 53 | 1990 | |
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| 4,870,084 Bicyclic benzo fused pyran compounds used for nausea treatment and prevention | 12 | 1988 | |
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| 5,369,131 Oral, cutaneous and intravaginal pharmaceutical compositions in the form of foam | 32 | 1993 | |
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| 5,278,126 Recording process and apparatus and recording medium in the same | 29 | 1990 | |
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| 5,109,135 2- or 3-aminomethyl-4-amino-3,4-dihydro-2H-1,4-benzoxazine intermediates | 10 | 1991 | |
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| 4,897,260 Compositions that affect suppression of cutaneous delayed hypersensitivity and products including same | 24 | 1988 | |
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| 5,292,362 Tissue bonding and sealing composition and method of using the same | 165 | 1991 | |
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| 5,266,465 .alpha.-1-antichymotrypsin, analogues and methods of production | 9 | 1991 | |
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| 5,403,867 Preparation for treating wounds or hemorrhoids | 15 | 1993 | |
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| 5,149,538 Misuse-resistive transdermal opioid dosage form | 97 | 1991 | |
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| 4,384,000 Method for treatment of various dermatological conditions | 9 | 1981 | |
| 5,229,127 Rapid miosis with control of intraocular pressure using a mixture of a cetylcholine and carbachol derivatives | 17 | 1990 | |
| 5,273,751 Composition for preventing clouding of paosterior capsule after extracapsular cataract eye surgery and method of performing cataract surgery | 22 | 1991 | |
| 5,282,851 Intraocular prostheses | 39 | 1992 | |