Stable expression of human A.sub.2B adenosine receptors, and assays employing the same
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United States of America Patent
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Dec 29, 1998
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Jun 20, 1996
filing date -
Jun 20, 1996
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Abstract
Stable over-expression of native and hexahistidine/FLAG extended recombinant human adenosine receptors permits recovery of membranes and membrane fragments bearing a high density of adenosine receptors. Cell lines expressing all four sub-types of human adenosine receptors have been identified. The receptors, and membranes and membrane fragments bearing the same, can be used in assays to screen compounds for binding ability to the adenosine receptors, such as potential pharmaceutical agents.
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