Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change

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United States of America Patent

PATENT NO 5855613
SERIAL NO

08542506

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Abstract

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Bioartificial implants and methods for their manufacture and use are described, particularly bioartificial pancreases. In particular, the implants may be thin sheets which enclose cells, may be completely biocompatible over extended periods of time and may not induce fibrosis. The high-density-cell-containing thin sheets are preferably completely retrievable, and have dimensions allowing maintenance of optimal tissue viability through rapid diffusion of nutrients and oxygen and also allowing rapid changes in the secretion rate of insulin and/or other bioactive agents in response to changing physiology. Implantations of living cells, tissue, drugs, medicines and/or enzymes, contained in the bioartificial implants may be made to treat and/or prevent disease.

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Patent Owner(s)

Patent OwnerAddress
ISLET SHEET MEDICAL INCSAN FRANCISCO CA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Antanavich, Richard D Paso Robles, CA 9 1549
Dorian, Randel Orinda, CA 45 4500

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