Compositions comprising complement related proteins and carbohydrates, and methods for producing and using said compositions
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United States of America Patent
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Jan 5, 1999
Grant Date -
N/A
app pub date -
Nov 13, 1995
filing date -
May 12, 1994
priority date (Note) -
Expired
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Abstract
The present invention provides compositions comprising at least one complement moiety and at least one carbohydrate moiety, and methods of producing such compositions. In particular, the compositions of the invention comprise complement proteins related to the complement receptor type I, and further comprise ligands for intracellular molecules, such as selectins. In a preferred embodiment, the compositions comprise a complement-related protein in combination with the Louis X antigen or the sialyl Lewis X antigen. The compositions of the invention have use in the diagnosis or therapy of disorders involving complement activity and inflammation. Pharmaceutical compositions are also provided for treating or reducing inflammation mediated by inappropriate complement activity and intercellular adhesion.
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