Pharmaceutical composition for cyclosporines
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United States of America Patent
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Jan 12, 1999
Grant Date -
N/A
app pub date -
Jan 22, 1997
filing date -
Jan 22, 1996
priority date (Note) -
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Abstract
The invention comprises a stable solution of cyclosporine forming a polar lipid self-emulsifying drug delivery system ('PLSEDDS'). The composition typically consists of cyclosporine dissolved in a polar lipid, such as a medium chain monoglyceride of C.sub.6 -C.sub.12 fatty acids having a monoglyceride content of at least 50% and a surfactant. The composition provided here instantly forms a fine emulsion on exposure to water. The encapsulated dosage form of this composition needs neither a hydrophilic component nor air-tight blister packaging, and is particularly suitable for oral administration.
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