US Patent No: 5,858,746

Number of patents in Portfolio can not be more than 2000

Gels for encapsulation of biological materials

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Abstract

Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMAUSTIN, TX2784

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Desai, Neil P Santa Monica, CA 160 4342
Hill, Jennifer L Austin, TX 9 1041
Hossainy, Syed F A Fremont, CA 178 6452
Hubbell, Jeffrey A Zurich, CH 120 3670
Pathak, Chandrashekhar P Austin, TX 73 2558
Sawhney, Amarpreet S Lexington, MA 109 3736

Cited Art

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4,193,845 Immobilization of enzymes or bacterial cells 20 1976
4,226,938 Method for immobilizing enzymes 27 1978
4,321,117 Process for preparing a polymer composition 61 1979
4,272,617 Immobilization of enzymes or bacteria cells 25 1979
4,359,483 Process for producing a multi-layered slow release composite 44 1981
4,411,754 Process for preparing a polymer composition 45 1981
 
REPLIGEN CORPORATION (4)
4,352,883 Encapsulation of biological material 405 1979
4,391,909 Microcapsules containing viable tissue cells 242 1981
4,409,331 Preparation of substances with encapsulated cells 128 1982
4,663,286 Encapsulation of materials 97 1984
 
ATRIX LABORATORIES, INC. (3)
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5,278,201 Biodegradable in-situ forming implants and methods of producing the same 221 1990
5,278,202 Biodegradable in-situ forming implants and methods of producing the same 186 1991
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (3)
5,410,016 Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers 379 1993
5,573,934 Gels for encapsulation of biological materials 184 1993
5,567,435 Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers 104 1995
 
COMPAGNIE ORIS INDUSTRIE S.A. (3)
4,283,325 Hydrophobic substrate which is able to release a chemical substance 13 1979
4,590,068 Inert cross-linked copolymer support, its preparation process and its use for producing delayed action medicaments 28 1983
4,729,904 Inert cross-linked copolymer support, its preparation process and its use for producing delayed action medicaments 7 1985
 
CONNAUGHT LABORATORIES LIMITED (2)
4,689,293 Microencapsulation of living tissue and cells 100 1984
4,806,355 Microencapsulation of living tissue and cells 104 1987
 
EASTMAN KODAK COMPANY (2)
5,066,376 Electrophoresis media comprising active methylene groups 7 1989
5,149,416 Polymeric electrophoresis media 14 1991
 
ETHICON, INC. (2)
4,741,337 Surgical fastener made from glycolide-rich polymer blends 113 1985
4,889,722 Method for inhibiting post-surgical adhesion formation by the topical administration of tissue plasminogen activator 44 1988
 
IMPERIAL CHEMICAL INDUSTRIES PLC (2)
4,526,938 Continuous release formulations 215 1983
4,942,035 Continuous release formulations 54 1985
 
KANSAI PAINT CO., LTD. (2)
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4,605,622 Process for producing granular fixed enzymes or microorganisms 26 1983
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (2)
4,744,933 Process for encapsulation and encapsulated active material system 71 1985
4,749,620 Encapsulated active material system 78 1985
 
UNITED STATES SURGICAL CORPORATION (2)
4,916,193 Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides 167 1988
5,185,408 Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lactides 94 1991
 
ABBOTT LABORATORIES (1)
5,268,182 Sustained-release drug dosage units of terazosin 21 1992
 
ALKERMES CONTROLLED THERAPEUTICS, INC. (1)
5,271,961 Method for producing protein microspheres 206 1992
 
ALZA CORPORATION (1)
4,913,903 Post-surgical applications for bioerodible polymers 39 1989
 
ARTHUR D. LITTLE, INC. (1)
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BAUSCH & LOMB INCORPORATED (1)
4,931,279 Sustained release formulation containing an ion-exchange resin 59 1988
 
BAYER AKTIENGESELLSCHAFT (1)
4,774,178 Immobilization of biological material within a polymer matrix 23 1985
 
BENZON PHARMA A/S (1)
5,288,500 Oral composition containing particles comprising an active substance 34 1992
 
BIOGLAN AB (1)
4,822,535 Method for producing small, spherical polymer particles 83 1986
 
BIOMEDICAL POLYMERS INTERNATIONAL, LTD. (1)
4,826,945 Biodegradable polymeric materials based on polyether glycols, processes for the preparation thereof and surgical articles made therefrom 132 1988
 
ENZON, INC. (1)
5,219,564 Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon 186 1991
 
EXXON RESEARCH AND ENGINEERING COMPANY (1)
4,376,059 Process for preparing artificial red cells 29 1980
 
FIDIA S.P.A. (1)
4,957,744 Cross-linked esters of hyaluronic acid 136 1987
 
FRAMATOME ANP GMBH (1)
5,271,901 Device having a diffusion sensor hose for detecting a leak 7 1992
 
GENETIC SYSTEMS CORPORATION (1)
4,511,478 Polymerizable compounds and methods for preparing synthetic polymers that integrally contain polypeptides 88 1983
 
HOECHST CELANESE CORPORATION (1)
5,145,906 Super-absorbent polymer having improved absorbency properties 86 1991
 
KAO SOAP CO., LTD. (1)
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MILLIPORE CORPORATION (1)
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N.V. SOPAR S.A. (1)
4,329,332 Biodegradable submicroscopic particles containing a biologically active substance and compositions containing them 66 1979
 
NALCO CHEMICAL COMPANY (1)
4,295,762 Grouting-soil conditioning systems using polyoxyethylene diacrylates 15 1980
 
NATIONAL PATENT DEVELOPMENT CORPORATION (1)
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ORTHO DIAGNOSTIC SYSTEMS INC. (1)
4,434,150 Immunological reagents employing polymeric backbone possessing reactive functional groups 53 1981
 
PALL CORPORATION (1)
5,209,849 Hydrophilic microporous polyolefin membrane 45 1992
 
PENNSYLVANIA RESEARCH CORPORATION, THE (1)
5,149,543 Ionically cross-linked polymeric microcapsules 153 1990
 
RENEURON, INC. (1)
5,334,640 Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods 99 1992
 
RICHARDS MEDICAL COMPANY (1)
4,804,691 Method for making a biodegradable adhesive for soft living tissue 137 1987
 
ROHM AND HAAS COMPANY (1)
5,432,210 Polymer particles and method for preparing by polymerization of encapsulated monomers 9 1993
 
ROHM GMBH (1)
4,829,101 Polymer particles and latices thereof for the immobilization of biologically active substances 19 1987
 
SHERWOOD SERVICES AG (1)
4,716,203 Diblock and triblock copolymers 68 1986
 
SHIDA, KEIZO (1)
4,652,443 Slow-release composite and process for producing the same 11 1984
 
SYNGENTA LIMITED (1)
4,745,160 Biodegradable amphipathic copolymers 116 1985
 
TAIWAN HOPAX CHEMS. MFG. CO., LTD. (1)
5,109,083 Process for making tacky acrylate microparticles and use therefor 5 1990
 
TECHNICON INSTRUMENTS CORPORATION (1)
4,376,839 Heat stable, polymer-forming composition 12 1980
 
THE DOW CHEMICAL COMPANY (1)
4,950,596 Stabilization of intracellular enzymes 16 1987
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
4,563,489 Biodegradable organic polymer delivery system for bone morphogenetic protein 216 1984
 
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (1)
5,183,690 Starch encapsulation of biologically active agents by a continuous process 63 1990
 
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (1)
4,637,931 Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material 104 1984
 
TRUSTEES OF BOSTON UNIVERSITY (1)
5,106,743 Hydrogels capable of supporting cell growth 10 1985
 
UNIVERSITE DE MONTREAL (1)
5,153,002 Biocompatible gradient controlled release implant 18 1991
 
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (1)
5,286,495 Process for microencapsulating cells 52 1992
 
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (1)
5,160,745 Biodegradable microspheres as a carrier for macromolecules 128 1990
 
UNIVERSITY OF WASHINGTON (1)
4,829,098 Immobilized biomolecules and method of making same 16 1986
 
WATSON PHARMACEUTICALS, INC. (1)
4,925,677 Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents 79 1988
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (2)
4,647,536 Method of encapsulating biomaterial in bead polymers 75 1983
4,888,413 Poly(propylene glycol fumarate) compositions for biomedical applications 41 1988

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ADVANCED CARDIOVASCULAR SYSTEMS, INC. (225)
6,790,228 Coating for implantable devices and a method of forming the same 165 2000
6,759,054 Ethylene vinyl alcohol composition and coating 113 2000
6,712,845 Coating for a stent and a method of forming the same 208 2001
7,682,669 Methods for covalently immobilizing anti-thrombogenic material into a coating on a medical device 1 2001
8,303,651 Polymeric coating for reducing the rate of release of a therapeutic substance from a stent 0 2001
7,223,282 Remote activation of an implantable device 4 2001
6,753,071 Rate-reducing membrane for release of an agent 203 2001
7,585,516 Coatings for drug delivery devices 4 2001
7,919,075 Coatings for implantable medical devices 1 2002
7,022,334 Therapeutic composition and a method of coating implantable medical devices 21 2002
7,396,539 Stent coatings with engineered drug release rate 22 2002
7,247,313 Polyacrylates coatings for implantable medical devices 32 2002
7,217,426 Coatings containing polycationic peptides for cardiovascular therapy 18 2002
7,070,798 Coatings for implantable medical devices incorporating chemically-bound polymers and oligomers of L-arginine 14 2002
7,056,523 Implantable medical devices incorporating chemically conjugated polymers and oligomers of L-arginine 6 2002
7,033,602 Polycationic peptide coatings and methods of coating implantable medical devices 10 2002
7,011,842 Polycationic peptide coatings and methods of making the same 7 2002
7,005,137 Coating for implantable medical devices 25 2002
6,994,867 Biocompatible carrier containing L-arginine 34 2002
6,733,768 Composition for coating an implantable prosthesis 109 2002
7,294,329 Poly(vinyl acetal) coatings for implantable medical devices 16 2002
7,175,873 Rate limiting barriers for implantable devices and methods for fabrication thereof 18 2002
7,491,233 Purified polymers for coatings of implantable medical devices 6 2002
7,363,074 Coatings comprising self-assembled molecular structures and a method of delivering a drug using the same 1 2002
7,201,935 Plasma-generated coatings for medical devices and methods for fabricating thereof 8 2002
7,438,722 Method for treatment of restenosis 3 2002
7,232,573 Stent coatings containing self-assembled monolayers 19 2002
7,404,979 Spin coating apparatus and a method for coating implantable devices 16 2002
7,087,263 Rare limiting barriers for implantable medical devices 11 2002
7,022,372 Compositions for coating implantable medical devices 2 2002
6,896,965 Rate limiting barriers for implantable devices 19 2002
6,982,004 Electrostatic loading of drugs on implantable medical devices 2 2002
7,211,150 Apparatus and method for coating and drying multiple stents 9 2002
7,776,926 Biocompatible coating for implantable medical devices 19 2002
7,094,256 Coatings for implantable medical device containing polycationic peptides 22 2002
6,908,624 Coating for implantable devices and a method of forming the same 84 2002
7,470,283 Biodegradable drug delivery material for stent 5 2003
7,390,333 Biodegradable drug delivery material for stent 8 2003
7,255,891 Method for coating implantable medical devices 5 2003
6,926,919 Method for fabricating a coating for a medical device 31 2003
7,288,609 Coatings for drug delivery devices based on poly (orthoesters) 7 2003
7,258,891 Stent mounting assembly and a method of using the same to coat a stent 13 2003
7,563,454 Coatings for implantable medical devices 14 2003
7,279,174 Stent coatings comprising hydrophilic additives 45 2003
7,323,209 Apparatus and method for coating stents 5 2003
7,186,789 Bioabsorbable, biobeneficial polyester polymers for use in drug eluting stent coatings 7 2003
7,682,647 Thermal treatment of a drug eluting implantable medical device 4 2003
7,285,304 Fluid treatment of a polymeric coating on an implantable medical device 17 2003
7,645,504 Coatings for implantable medical devices comprising hydrophobic and hydrophilic polymers 2 2003
7,875,285 Medicated coatings for implantable medical devices having controlled rate of release 0 2003
7,169,404 Biologically absorbable coatings for implantable devices and methods for fabricating the same 6 2003
7,056,591 Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same 45 2003
7,645,474 Method and system of purifying polymers for use with implantable medical devices 7 2003
7,431,959 Method and system for irradiation of a drug eluting implantable medical device 8 2003
6,986,899 Composition for coating an implantable prosthesis 24 2003
7,390,523 Method of forming a diffusion barrier layer for implantable devices 7 2003
8,361,539 Methods of forming microparticle coated medical device 0 2003
7,441,513 Plasma-generated coating apparatus for medical devices and a method of coating deposition 3 2003
7,318,932 Coatings for drug delivery devices comprising hydrolitically stable adducts of poly(ethylene-co-vinyl alcohol) and methods for fabricating the same 2 2003
7,198,675 Stent mandrel fixture and method for selectively coating surfaces of a stent 46 2003
6,953,560 Barriers for polymer-coated implantable medical devices and methods for making the same 47 2003
7,704,544 System and method for coating a tubular implantable medical device 0 2003
7,682,648 Methods for forming polymeric coatings on stents 1 2003
7,329,413 Coatings for drug delivery devices having gradient of hydration and methods for fabricating thereof 8 2003
7,678,143 Ethylene-carboxyl copolymers as drug delivery matrices 0 2003
7,261,946 Block copolymers of acrylates and methacrylates with fluoroalkenes 7 2003
8,192,752 Coatings for implantable devices including biologically erodable polyesters and methods for fabricating the same 0 2003
7,560,492 Polysulfone block copolymers as drug-eluting coating material 13 2003
7,807,722 Biobeneficial coating compositions and methods of making and using thereof 0 2003
7,335,391 Method for coating implantable devices 8 2003
7,220,816 Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same 32 2003
7,435,788 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 5 2003
8,309,112 Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same 0 2003
7,563,324 System and method for coating an implantable medical device 19 2003
7,820,190 Coating for implantable devices and a method of forming the same 4 2004
7,014,913 Rate-reducing membrane for release of an agent 7 2004
7,699,890 Medicated porous metal prosthesis and a method of making the same 1 2004
7,115,300 Method of coating implantable medical devices 5 2004
7,758,880 Biocompatible polyacrylate compositions for medical applications 0 2004
7,364,748 Controlled morphologies in polymer drug for release of drugs from polymer films 2 2004
7,807,210 Hemocompatible polymers on hydrophobic porous polymers 0 2004
7,553,377 Apparatus and method for electrostatic coating of an abluminal stent surface 5 2004
8,293,890 Hyaluronic acid based copolymers 0 2004
7,820,732 Methods for modulating thermal and mechanical properties of coatings on implantable devices 0 2004
7,785,512 Method and system of controlled temperature mixing and molding of polymers with active agents for implantable medical devices 6 2004
7,807,211 Thermal treatment of an implantable medical device 4 2004
7,563,780 Heparin prodrugs and drug delivery stents formed therefrom 3 2004
7,329,366 Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability 5 2004
7,077,860 Method of reducing or eliminating thrombus formation 13 2004
8,172,897 Polymer and metal composite implantable medical devices 0 2004
7,297,159 Selective coating of medical devices 3 2004
8,357,391 Coatings for implantable devices comprising poly (hydroxy-alkanoates) and diacid linkages 0 2004
7,494,665 Polymers containing siloxane monomers 2 2004
7,311,980 Polyactive/polylactic acid coatings for an implantable device 8 2004
7,648,727 Methods for manufacturing a coated stent-balloon assembly 0 2004
7,244,443 Polymers of fluorinated monomers and hydrophilic monomers 6 2004
7,229,471 Compositions containing fast-leaching plasticizers for improved performance of medical devices 55 2004
8,110,211 Medicated coatings for implantable medical devices including polyacrylates 0 2004
8,173,062 Controlled deformation of a polymer tube in fabricating a medical article 0 2004
8,043,553 Controlled deformation of a polymer tube with a restraining surface in fabricating a medical article 1 2004
8,052,912 Temperature controlled crimping 0 2004
7,166,680 Blends of poly(ester amide) polymers 14 2004
7,481,835 Encapsulated covered stent 4 2004
7,390,497 Poly(ester amide) filler blends for modulation of coating properties 9 2004
7,214,759 Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same 8 2004
7,588,642 Abluminal stent coating apparatus and method using a brush assembly 1 2004
7,892,592 Coating abluminal surfaces of stents and other implantable medical devices 0 2004
7,632,307 Abluminal, multilayer coating constructs for drug-delivery stents 3 2004
7,604,818 Polymers of fluorinated monomers and hydrocarbon monomers 0 2004
7,419,504 Poly(ester amide) block copolymers 3 2004
8,007,775 Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same 2 2004
7,202,325 Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles 16 2005
7,387,810 Method of forming rate limiting barriers for implantable devices 6 2005
7,563,483 Methods for fabricating a coating for implantable medical devices 1 2005
7,063,884 Stent coating 16 2005
7,247,364 Coating for implantable medical devices 7 2005
7,732,535 Coating for controlled release of drugs from implantable medical devices 0 2005
7,758,881 Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device 1 2005
7,381,048 Stents with profiles for gripping a balloon catheter and molds for fabricating stents 2 2005
7,795,467 Bioabsorbable, biobeneficial polyurethanes for use in medical devices 2 2005
7,637,941 Endothelial cell binding coatings for rapid encapsulation of bioerodable stents 17 2005
7,691,401 Poly(butylmethacrylate) and rapamycin coated stent 20 2005
7,291,166 Polymeric stent patterns 10 2005
7,875,283 Biodegradable polymers for use with implantable medical devices 2 2005
7,622,070 Method of manufacturing an implantable polymeric medical device 5 2005
7,823,533 Stent fixture and method for reducing coating defects 0 2005
8,021,676 Functionalized chemically inert polymers for coatings 3 2005
8,067,023 Implantable medical devices incorporating plasma polymerized film layers and charged amino acids 0 2005
7,875,233 Method of fabricating a biaxially oriented implantable medical device 3 2005
7,785,647 Methods of providing antioxidants to a drug containing product 0 2005
7,735,449 Stent fixture having rounded support structures and method for use thereof 6 2005
7,658,880 Polymeric stent polishing method and apparatus 1 2005
7,297,758 Method for extending shelf-life of constructs of semi-crystallizable polymers 1 2005
7,449,210 Electrostatic loading of drugs on implantable medical devices 4 2005
7,476,245 Polymeric stent patterns 3 2005
7,875,286 Polycationic peptide coatings and methods of coating implantable medical devices 0 2005
7,803,406 Polycationic peptide coatings and methods of coating implantable medical devices 0 2005
7,794,743 Polycationic peptide coatings and methods of making the same 0 2005
7,985,440 Method of using a mandrel to coat a stent 1 2005
7,396,541 Heparin prodrugs and drug delivery stents formed therefrom 2 2005
8,202,530 Biocompatible coatings for stents 0 2005
7,976,891 Abluminal stent coating apparatus and method of using focused acoustic energy 1 2005
7,591,841 Implantable devices for accelerated healing 0 2005
7,867,547 Selectively coating luminal surfaces of stents 0 2005
7,638,156 Apparatus and method for selectively coating a medical article 19 2005
7,951,185 Delivery of a stent at an elevated temperature 2 2006
7,601,383 Coating construct containing poly (vinyl alcohol) 1 2006
7,713,637 Coating containing PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid polymer 1 2006
7,989,018 Fluid treatment of a polymeric coating on an implantable medical device 1 2006
7,455,907 Hydrophobic biologically absorbable coatings for drug delivery devices and methods for fabricating the same 3 2006
8,304,012 Method for drying a stent 0 2006
8,069,814 Stent support devices 1 2006
8,003,156 Rotatable support elements for stents 1 2006
7,648,725 Clamp mandrel fixture and a method of using the same to minimize coating defects 1 2006
7,572,336 Clamp mandrel fixture and a method of using the same to minimize coating defects 2 2006
7,761,968 Method of crimping a polymeric stent 4 2006
7,775,178 Stent coating apparatus and method 0 2006
7,959,940 Polymer-bioceramic composite implantable medical devices 1 2006
8,114,150 RGD peptide attached to bioabsorbable stents 1 2006
7,731,890 Methods of fabricating stents with enhanced fracture toughness 0 2006
8,333,000 Methods for improving stent retention on a balloon catheter 0 2006
7,794,776 Modification of polymer stents with radiation 2 2006
7,740,791 Method of fabricating a stent with features by blow molding 0 2006
7,998,404 Reduced temperature sterilization of stents 0 2006
7,757,543 Radio frequency identification monitoring of stents 1 2006
7,794,495 Controlled degradation of stents 3 2006
7,886,419 Stent crimping apparatus and method 0 2006
7,357,793 Polymers of fluorinated and hydrophilic monomers 17 2006
7,601,384 Method of coating implantable medical devices 1 2006
7,923,022 Degradable polymeric implantable medical devices with continuous phase and discrete phase 1 2006
8,173,199 40-O-(2-hydroxy)ethyl-rapamycin coated stent 0 2006
7,842,737 Polymer blend-bioceramic composite implantable medical devices 1 2006
7,622,146 Rate limiting barriers for implantable devices and methods for fabrication thereof 0 2006
7,803,394 Polycationic peptide hydrogel coatings for cardiovascular therapy 0 2006
7,875,073 Block copolymers of acrylates and methacrylates with fluoroalkenes 0 2006
7,365,133 Blends of poly(ester amide) polymers 0 2006
7,378,106 Biologically absorbable coatings for implantable devices and methods for fabricating the same 3 2006
7,312,299 Bioabsorbabl, biobeneficial polyester polymers for stent coatings 1 2006
7,301,001 Bioabsorbable, biobeneficial polyester polymers for stent coatings 1 2006
8,034,361 Stent coatings incorporating nanoparticles 1 2006
8,197,879 Method for selectively coating surfaces of a stent 0 2007
7,604,700 Stent mandrel fixture and method for selectively coating surfaces of a stent 1 2007
7,361,726 Poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles 2 2007
8,067,025 Nitric oxide generating medical devices 0 2007
8,109,230 Apparatus and method for coating and drying multiple stents 0 2007
7,538,180 Biologically absorbable coatings for implantable devices based on poly(ester amides) and methods for fabricating the same 0 2007
7,534,464 Apparatus and method for coating and drying multiple stents 0 2007
7,901,703 Polycationic peptides for cardiovascular therapy 0 2007
7,662,326 Compositions containing fast-leaching plasticizers for improved performance of medical devices 1 2007
7,413,746 Stent coatings containing self-assembled monolayers 4 2007
8,017,140 Drug-delivery stent formulations for restenosis and vulnerable plaque 0 2007
7,766,884 Polymers of fluorinated monomers and hydrophilic monomers 0 2007
7,955,381 Polymer-bioceramic composite implantable medical device with different types of bioceramic particles 0 2007
8,007,855 Method for coating implantable medical devices 0 2007
7,588,794 Coatings for drug delivery devices based on poly (orthoesters) 0 2007
8,109,994 Biodegradable drug delivery material for stent 1 2008
7,967,998 Method of polishing implantable medical devices to lower thrombogenecity and increase mechanical stability 0 2008
7,749,554 Method for coating stents 0 2008
8,277,926 Methods for fabricating coatings for drug delivery devices having gradient of hydration 0 2008
8,231,962 Coatings for drug delivery devices having gradient of hydration 0 2008
8,052,988 Methods for fabricating coatings for drug delivery devices having gradient of hydration 0 2008
7,945,319 Methods of delivering a drug using a medical device with a coating comprising a self-assembled molecular structure 0 2008
7,941,212 Method of delivering a drug using a medical device with a coating comprising a self-assembled molecular structure 0 2008
7,536,221 Coatings comprising self-assembled molecular structures 1 2008
7,520,891 Blends of poly(ester amide) polymers 1 2008
7,507,251 Blends of poly(ester amide) polymers 0 2008
7,708,548 Molds for fabricating stents with profiles for gripping a balloon catheter 1 2008
7,699,889 Poly(ester amide) block copolymers 0 2008
8,003,123 Biologically absorbable coatings for implantable devices and methods for fabricating the same 0 2008
8,110,243 Coating for a stent and a method of forming the same 0 2008
8,042,486 Stent spin coating apparatus 1 2008
7,604,831 Stent spin coating method 1 2008
8,007,529 Medicated porous metal prosthesis 2 2008
7,887,871 Method and system for irradiation of a drug eluting implantable medical device 0 2008
7,786,249 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 0 2008
7,772,359 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 0 2008
7,632,914 Biobeneficial polyamide/polyethylene glycol polymers for use with drug eluting stents 0 2008
8,414,642 Biodegradable stent of a polyorthoester polymer or a polyanhydride polymer 0 2008
8,007,858 System and method for coating implantable devices 2 2009
8,017,142 Polysulfone block copolymers as drug-eluting coating material 0 2009
8,367,091 Coatings for implantable medical devices 0 2009
8,097,268 Coatings for implantable medical devices 0 2009
8,349,350 Coatings for drug delivery devices 0 2009
8,124,119 Coatings for drug delivery devices 0 2009
8,293,367 Nanoshells on polymers 0 2011
 
ABBOTT CARDIOVASCULAR SYSTEMS INC. (30)
7,504,125 System and method for coating implantable devices 8 2001
7,964,210 Degradable polymeric implantable medical devices with a continuous phase and discrete phase 0 2006
7,985,441 Purification of polymers for coating applications 1 2006
8,048,448 Nanoshells for drug delivery 0 2006
8,017,237 Nanoshells on polymers 0 2006
8,099,849 Optimizing fracture toughness of polymeric stent 0 2006
8,343,530 Polymer-and polymer blend-bioceramic composite implantable medical devices 0 2006
7,569,655 Biologically absorbable coatings for implantable devices based on polyesters and methods for fabricating the same 1 2007
8,262,723 Implantable medical devices fabricated from polymer blends with star-block copolymers 0 2007
8,029,816 Medical device coated with a coating containing elastin pentapeptide VGVPG 7 2007
8,034,287 Radiation sterilization of medical devices 3 2007
8,147,769 Stent and delivery system with reduced chemical degradation 0 2007
7,951,194 Bioabsorbable stent with radiopaque coating 0 2007
7,829,008 Fabricating a stent from a blow molded tube 2 2007
7,959,857 Radiation sterilization of medical devices 2 2007
8,293,260 Elastomeric copolymer coatings containing poly (tetramethyl carbonate) for implantable medical devices 0 2007
8,202,528 Implantable medical devices with elastomeric block copolymer coatings 4 2007
8,425,591 Methods of forming polymer-bioceramic composite medical devices with bioceramic particles 0 2007
8,128,688 Carbon coating on an implantable device 0 2007
8,109,904 Drug delivery medical devices 0 2007
8,048,441 Nanobead releasing medical devices 0 2007
8,016,879 Drug delivery after biodegradation of the stent scaffolding 1 2007
7,901,452 Method to fabricate a stent having selected morphology to reduce restenosis 8 2007
7,823,263 Method of removing stent islands from a stent 0 2007
7,749,263 Poly(ester amide) filler blends for modulation of coating properties 0 2008
8,118,863 RGD peptide attached to bioabsorbable stents 0 2008
8,062,350 RGD peptide attached to bioabsorbable stents 0 2008
8,337,937 Stent spin coating method 0 2008
8,435,550 Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device 0 2008
8,211,489 Methods for applying an application material to an implantable device 0 2008
 
NEOMEND, INC. (13)
6,371,975 Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers 67 1998
6,458,147 Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue 64 1999
6,899,889 Biocompatible material composition adaptable to diverse therapeutic indications 12 2000
6,949,114 Systems, methods, and compositions for achieving closure of vascular puncture sites 14 2001
6,830,756 Systems, methods, and compositions for achieving closure of vascular puncture sites 22 2001
6,994,686 Systems for applying cross-linked mechanical barriers 29 2001
7,279,001 Systems, methods, and compositions for achieving closure of vascular puncture sites 6 2002
7,318,933 Systems, methods, and compositions for achieving closure of vascular puncture sites 3 2004
7,247,314 Biocompatible material composition adaptable to diverse therapeutic indications 3 2004
8,034,367 Tissue adhering compositions 3 2007
8,221,452 Systems and methods for sealing a vascular puncture 0 2008
8,409,605 Biocompatible material composition adaptable to diverse therapeutic indications 0 2009
8,383,144 Tissue adhering compositions 0 2009
 
ENVISIONTEC GMBH (11)
7,845,930 Process for the production of a three-dimensional object with an improved separation of hardened material layers from a construction plane 1 2005
7,790,093 Process for the production of a three-dimensional object with resolution improvement by “pixel-shift” 4 2005
7,892,474 Continuous generative process for producing a three-dimensional object 0 2006
7,894,921 Device and method for producing a three-dimensional object by means of mask exposure 2 2007
7,783,371 Device and method for producing a three-dimensional object by means of mask exposure 2 2007
7,831,328 Method and device for producing a three-dimensional object, and computer and data carrier useful therefor 2 2008
8,110,135 Process and freeform fabrication system for producing a three-dimensional object 0 2008
8,003,040 Process and freeform fabrication system for producing a three-dimensional object 0 2008
8,126,580 Device and method for producing a three-dimensional object by means of mask exposure 0 2010
8,394,313 Process for the production of a three-dimensional object with an improved separation of hardened material layers from a construction plane 0 2010
RE43955 Process for the production of a three-dimensional object with resolution improvement by pixel-shift 0 2011
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (9)
7,097,855 Transdermal thermal polymerization 3 2000
6,699,470 Mesh-gel constructs for cell delivery containing enzymes and/or enzyme inhibitors to control gel degradation 4 2000
6,998,115 Biodegradable poly(β-amino esters) and uses thereof 14 2001
7,112,361 Methods of making decomposable thin films of polyelectrolytes and uses thereof 11 2002
7,943,179 pH triggerable polymeric particles 0 2004
8,105,652 Methods of making decomposable thin films of polyelectrolytes and uses thereof 0 2006
8,071,082 End-modified poly(beta-amino esters) and uses thereof 0 2007
8,287,849 Biodegradable poly(beta-amino esters) and uses thereof 0 2009
RE43612 Biodegradable poly(β-amino esters) and uses thereof 0 2009
 
COVIDIEN LP (6)
7,402,320 Apparatus, material compositions, and methods for permanent occlusion of a hollow anatomical structure 5 2005
8,262,695 Structures for permanent occlusion of a hollow anatomical structure 0 2006
7,972,354 Method and apparatus for impeding migration of an implanted occlusive structure 3 2006
8,011,370 Method for permanent occlusion of fallopian tube 1 2008
8,333,786 Method and apparatus for implanting an occlusive structure 0 2010
8,333,201 Method for permanent occlusion of fallopian tube 0 2011
 
INCEPT LLC (6)
6,514,534 Methods for forming regional tissue adherent barriers and drug delivery systems 59 1998
7,025,990 Methods for forming regional tissue adherent barriers and drug delivery systems 18 2002
7,413,752 Composite hydrogel drug delivery systems 2 2003
7,597,882 Protein crosslinkers, crosslinking methods and applications thereof 2 2007
8,003,705 Biocompatible hydrogels made with small molecule precursors 1 2008
8,409,606 Drug delivery through hydrogel plugs 0 2010
 
UNIVERSITAT ZURICH (6)
7,744,912 Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups 5 2000
6,958,212 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds 21 2000
7,291,673 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds 5 2001
7,132,475 Block copolymers for multifunctional self-assembled systems 2 2001
7,413,739 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds 3 2005
7,670,605 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds 2 2008
 
BATTELLE MEMORIAL INSTITUTE (5)
6,979,464 Reversible geling co-polymer and method of making 7 1998
6,660,247 Multiple stimulus reversible hydrogels 11 2000
6,841,617 Thermogelling biodegradable aqueous polymer solution 6 2001
7,087,244 Thermogelling oligopeptide polymers 4 2002
7,033,571 Multiple stimulus reversible hydrogels 16 2003
 
SURMODICS, INC. (5)
6,156,345 Crosslinkable macromers bearing initiator groups 50 1999
6,410,044 Crosslinkable macromers 48 2000
6,924,370 Crosslinkable macromers 3 2002
7,094,418 Crosslinkable macromers 4 2004
7,547,445 Crosslinkable macromers 33 2006
 
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (4)
6,258,870 Gels for encapsulation of biological materials 37 1997
6,962,716 Compositions and methods for biodegradable microspheres as carriers of bioactive substances 1 2000
7,291,348 Compositions and methods for biodegradable microspheres as carriers of bioactive substances 0 2005
7,413,781 Gels for encapsulation of biological materials 1 2006
 
ETHICON, INC. (4)
6,423,818 Coumarin endcapped absorbable polymers 15 2000
7,144,976 Coumarin endcapped absorbable polymers 2 2002
7,105,629 Coumarin endcapped absorbable polymers 1 2002
7,012,126 Coumarin endcapped absorbable polymers 3 2002
 
CO2 SOLUTION INC. (3)
8,329,458 containing gas effluent treatment 0 2010
8,329,459 containing gas effluent treatment 0 2010
8,329,460 Carbonic anhydrase bioreactor and process 0 2011
 
PERSONICS HOLDINGS INC. (3)
8,221,861 Earguard sealing system II: single-chamber systems 0 2008
8,221,860 Earguard sealing system I: multi-chamber systems 0 2008
8,142,870 Energy responsive conformal device 0 2008
 
SYNTHEMED, INC. (3)
7,879,356 Polymeric compositions 0 2001
7,202,281 Methods and compositions for reducing or eliminating post-surgical adhesion formation 4 2003
7,569,643 Reverse thermal gellation polymer of chain-extended optional polyester-terminated PEO-PPO-PEO 0 2004
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (3)
7,381,404 Treatment for dry macular degeneration 1 2003
7,727,544 Treatment of myopia 0 2005
8,298,521 Treatment for eye disorder 0 2008
 
FZIOMED, INC. (2)
6,566,345 Polyacid/polyalkylene oxide foams and gels and methods for their delivery 29 2001
7,265,098 Polyacid/polyalkylene oxide gels and methods for their delivery 4 2003
 
GENZYME CORPORATION (2)
6,639,014 Multiblock biodegradable hydrogels for drug delivery and tissue treatment 18 2002
6,923,986 Multiblock biodegradable hydrogels for drug delivery and tissue treatment 11 2003
 
NOVOCELL, INC. (2)
6,911,227 Gels for encapsulation of biological materials 10 2001
7,427,415 Implantation of encapsulated biological materials for treating diseases 6 2003
 
PERICOR SCIENCE, INC. (2)
6,919,076 Conjugates of agents and transglutaminase substrate linking molecules 8 1999
6,958,148 Linkage of agents to body tissue using microparticles and transglutaminase 7 2000
 
REGENTIS BIOMATERIALS LTD. (2)
8,007,774 Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same 0 2006
7,842,667 Matrix composed of a naturally-occurring protein backbone cross linked by a synthetic polymer and methods of generating and using same 1 2006
 
SYNTHASOME, INC. (2)
7,862,831 Method and material for enhanced tissue-biomaterial integration 0 2003
7,897,165 Method and material for enhanced tissue-biomaterial integration 0 2006
 
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (2)
8,216,259 Compositions and methods for joining non-conjoined lumens 0 2007
8,197,499 Compositions and methods for joining non-conjoined lumens 0 2008
 
UNIVERSITY OF CONNECTICUT (2)
6,316,153 Free-form fabricaton using multi-photon excitation 102 1999
6,713,772 Free-form fabrication using multi-photon excitation 8 2001
 
ABBOTT LABORATORIES (1)
8,361,538 Methods for applying an application material to an implantable device 0 2008
 
ABRAXIS BIOSCIENCE, LLC (1)
8,137,684 Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof 1 2006
 
ACCESS PHARMACEUTICALS, INC. (1)
6,521,431 Biodegradable cross-linkers having a polyacid connected to reactive groups for cross-linking polymer filaments 14 1999
 
ADVANCED CLOSURE SYSTEMS, INC. (1)
6,743,248 Pretreatment method for enhancing tissue adhesion 25 2000
 
BIOMET BIOLOGICS, LLC (1)
8,361,005 Blood separation and concentration system 0 2010
 
BOSTON SCIENTIFIC SCIMED, INC. (1)
7,052,512 Fluorescent dyed lubricant for medical devices 1 2001
 
CLEMSON UNIVERSITY (1)
6,991,652 Tissue engineering composite 3 2001
 
CONFLUENT SURGICAL, INC. (1)
8,067,028 Drug delivery device 0 2008
 
EBARA TECHNOLOGIES, INC. (1)
7,971,333 Manufacturing process for polymetric stents 3 2006
 
GLOBAL FILTRATION SYSTEMS, A DBA OF GULF FILTRATION SYSTEMS INC. (1)
8,372,330 Resin solidification substrate and assembly 0 2010
 
INTARCIA THERAPEUTICS, INC. (1)
7,727,519 Method for treating hepatitis C virus with omega interferon 1 2004
 
INTERPORE ORTHOPAEDICS, A DELAWARE CORPORATION (1)
7,806,845 Blood separation and concentration system 1 2003
 
IXION BIOTECHNOLOGY, INC. (1)
6,703,017 Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures 18 1999
 
MONSANTO TECHNOLOGY LLC (1)
6,453,608 Gellan gum seed coating 3 1999
 
SOLANA THERAPEUTICS, INC. (1)
6,500,807 Modified pectin and nucleic acid composition 6 2000
 
TAUTONA GROUP, L.P. (1)
8,172,861 Compositions and methods for joining non-conjoined lumens 0 2008
 
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (1)
7,427,394 Biodegradable poly(.beta.-amino esters) and uses thereof 10 2003