Activated esters of 1-phenylpyrazolin-5-one for labeling amine-functionalized molecules
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United States of America Patent
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Jan 12, 1999
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N/A
app pub date -
Aug 15, 1996
filing date -
Apr 29, 1994
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Abstract
The disclosed invention is drawn to pyrazolinone derivatives, and methods of use thereof, for non-radioactive labeling of amine-functionalized molecules, especially biomolecules such as DNA, RNA, PNA, oligomers, carbohydrates, amino acids and peptides. Carboxyl-containing reporter groups such as biotin and fluorescein may be activated for nucleophilic addition to a primary or secondary amine moiety. Representative compounds of the invention include Dimethoxytritylbiotin-XPP, biotin-XPP, and fluorescein-XPP.
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