Importance

Loading Importance Indicators...

Abstract

Nucleic acid able to cause specific cleavage of a bond between two ribonucleotides in an RNA-containing molecule. The RNA-containing molecule has the structure: 5'-XnUHZCUGANGAGYm-3' wherein each X and Y is independently any nucleotide base; n and m are independently between 5 and 40; H is U, A or C; Z is a hairpin loop, having between 6 and 60 bases, and each U, C, G and A is a uracil, cytosine, guanosine, or adenosine-containing ribonucleotide, respectively, and N is any ribonucleotide. The nucleic acid has the structure: 3'-X'nM.sub.0 Y'm-5' wherein each X' and Y' are complementary nucleotide bases to each corresponding X and Y, and M.sub.0 is a series of nucleotide bases active to cause the cleavage, and wherein M.sub.0 contains no ribonucleotides.

Loading the Abstract Image...

First Claim