Antisense oligonucleotides to inhibit expression of mutated and wild type genes for collagen
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United States of America Patent
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Jan 19, 1999
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N/A
app pub date -
Jun 30, 1995
filing date -
Nov 9, 1992
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Expired
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Abstract
The present invention is directed to oligonucleotides that inhibit mutant COL1A1 and/or wild type COL1A1 gene expression. The present invention is further directed to methods of inhibiting mutant and/or wild type collagen gene expression using the disclosed inhibitory oligonucleotides. The oligonucleotides and methods of the present invention are useful for the treatment of mammals having diseases related to inappropriate mutant or wild type COL1A1 gene expression.
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