Systematic evolution of ligands by exponential enrichment: tissue selex
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United States of America Patent
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Jan 26, 1999
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N/A
app pub date -
May 3, 1995
filing date -
Jun 11, 1990
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Abstract
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to red blood cells ghosts, glioblastomas, and lymphomas are described.
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