Synthesis of isoimide of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer

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United States of America Patent

PATENT NO 5864035
SERIAL NO

08812029

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Compounds having utility as light absorbing compounds, especially in the area of photodynamic therapy. Such compounds have the formula: ##STR1## where z is .dbd.O or NR.sub.14 ; R.sub.14 is alkyl or substituted alkyl; R.sub.1 is an amino acid group, a polyamine group, a polyether group or OR.sub.13 where R.sub.13 is alkyl; R.sub.4 through R.sub.11 are --H, --OH alkyl, alkoxy, alkenyl, alkylene, aryl, or aryloxy, or a carbonyl containing group, wherein carbon containing groups may be substituted with carbonyl, hydroxy, phosphoro, carboxy, halo, sulfo, amino and ether substituents, provided that; R.sub.4 may be taken together with R.sub.7 to form .dbd.O; R.sub.8 may be taken together with R.sub.9 to form .dbd.O; R.sub.10 may be taken together with R.sub.11 to form .dbd.O; and R.sub.4 and R.sub.7 may together form a chemical bond and R.sub.8 and R.sub.11 may together form a chemical bond; and R.sub.12 is hydrogen or lower alkyl; provided that if one z is O, the other z is --NR.sub.14.

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Patent Owner(s)

  • HEALTH RESEARCH, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dougherty, Thomas J Grand Island, NY 129 6200
Kozyrev, Andrei N Amherst, NY 2 45
Pandey, Ravindra K Williamsville, NY 61 1007

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