Transactivation method of regulating foreign gene expression

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United States of America Patent

PATENT NO 5866359
SERIAL NO

08442646

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Abstract

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The present invention provides a process and host cell for use in increasing the amount of a desired protein produced by a cell line. The process and the cell line use a first transcription unit containing a gene for a transactivator protein to control the transactivation of a second transcription unit such that the amount of desired protein expression can be increased without affecting adversely cell growth. Preferred transactivator proteins are derived from E1A.

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Patent Owner(s)

Patent OwnerAddress
LONZA GROUP AGBASEL SUI BASEL BASEL-STADT

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bebbington, Christopher Robert Windsor, GB 40 533
Cockett, Mark Ian Maidenhead, GB 6 40
Yarranton, Geoffrey Thomas Winnersh, GB 9 169

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