Gene transfer into the kidney
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United States of America Patent
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Feb 9, 1999
Grant Date -
N/A
app pub date -
Mar 30, 1995
filing date -
Mar 30, 1995
priority date (Note) -
Expired
status (Latency Note)
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Abstract
This invention pertains to a method of infecting an organ or a tissue other than a liver with an effective amount of a vector carrying genetic material of interest. This invention features a method of infecting kidney cells by introducing into the vasculature of a kidney a vector carrying genetic material of interest and maintaining the vector in contact with the renal vasculature for a period of time sufficient to allow infection of kidney cells with an effective amount of the vector, and under conditions which protect the kidney from ischemic damage. This method allows for infection of a significant number of renal endothelial cells. The method of the invention can be used for both in vivo and ex vivo applications.
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