Triplex Oligonucleotides targeted to p120
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United States of America Patent
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Feb 9, 1999
Grant Date -
N/A
app pub date -
Jun 12, 1996
filing date -
Oct 14, 1994
priority date (Note) -
Expired
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Abstract
This invention provides a method for inhibiting transcription of a p120 gene, which comprises using an oligonucleotide capable of forming a triple-stranded chain in a homopurine/homopyrimidine region of the p120 gene, as well as an oligonucleotide capable of forming a triple-stranded chain, or a derivative thereof, which has the following nucleotide sequence GAAWGGAGGAGGAGAAA or a complementary sequence thereof, and a pharmaceutical composition which contains the oligonucleotide as its active ingredient and is useful as an agent for the prevention and treatment of cancers with less side effects.
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