Stable mutants of D-N-.alpha.-carbamoylase and process for preparing D-.alpha.-amino acids
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United States of America Patent
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Feb 9, 1999
Grant Date -
N/A
app pub date -
Apr 3, 1995
filing date -
Apr 15, 1994
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Expired
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Abstract
The present invention relates to mutants of D-N-.alpha.-carbamylase wherein at least one of the cysteines in position 243, 250 and 279 of the amino acid sequence of the wild type enzyme is substituted with a different residue selected from natural amino acids; a recombinant plasmid comprising a nucleotidic sequence which encodes for at least one of the mutants of D-N-.alpha.-carbamylase, host microorganisms transformed with said plasmid and a process for the preparation of these mutants by the culture of said microorganisms. The mutants of D-N-.alpha.-carbamylase have a higher enzymatic stability than that of the wild type enzyme and are particularly useful in the preparation of D-.alpha.-amino acids providing an improvement in the production yields.
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