C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 5869519
SERIAL NO

08767175

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

This invention is directed to novel (N-substituted)indole ICE-inhibitor compounds. The invention is also directed to pharmaceutical compositions of such indole compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
CONATUS PHARMACEUTICALS, INC.SAN DIEGO, CA18

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bai, Xu Carlsbad, CA 14 114
Karanewsky, Donald S Escondido, CA 123 1254

Cited Art Landscape

Patent Info (Count) # Cites Year
 
CEPHALON, INC. (1)
* 5498616 Cysteine protease and serine protease inhibitors 49 1994
 
Prototek, Inc. (1)
* 5486623 Cysteine protease inhibitors containing heterocyclic leaving groups 53 1993
 
GEORGIA TECH RESEARCH CORPORATION (1)
* 5514694 Peptidyl ketoamides 37 1993
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (3)
* 2004/0198,716 Cysteine protease inhimbitors 6 2004
* 2005/0192,231 Dipeptide apoptosis inhibitors and the use thereof 1 2005
* 8389474 Rationale for IL-1 β targeted therapy to improve harvested organ viability, allograft tolerance, replant success and for conditions characterized by reduced or absent arterial perfusion 0 2010
 
THE J. DAVID GLADSTONE INSTITUTES (1)
9352010 Treatment of HIV-1 infection and AIDS 0 2015
 
VERTEX PHARMACEUTICALS INCORPORATED (9)
7417029 Prodrug of an ice inhibitor 7 2001
* 2002/0013,278 Prodrug of an ice inhibitor 4 2001
7531570 Treatment of diseases using ICE inhibitors 1 2005
* 2005/0267,101 Treatment of diseases using ICE inhibitors 11 2005
8691848 Inhibitors of caspases 0 2008
* 2009/0048,226 Inhibitors of caspases 0 2008
8022041 Prodrug of an ICE inhibitor 3 2008
9156880 Prodrug of an ice inhibitor 0 2012
9487555 Prodrug of an ice inhibitor 0 2015
 
CONATUS PHARMACEUTICALS, INC. (9)
* 6197750 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases 21 1998
6544951 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases 4 2000
* 6489353 C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases 0 2000
7053056 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases 0 2001
* 2002/0042,376 C-terminal modified oxamyl dipeptides as inhibitors of the ICE-ced-3 family of cysteine proteases 2 2001
6790989 Inhibitors of the ICE/ced-3 family of cysteine proteases 0 2001
* 2002/0137,686 Inhibitors of the ICE/ced-3 family of cysteine proteases 0 2001
* 6610683 Treatment of infectious disease using interleukin-1.beta.-converting enzyme (ICE)/CED-3 family inhibitors 1 2001
7183260 C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases 0 2004
 
OSI PHARMACEUTICALS, INC. (7)
* 6156528 Methods for using a phosphodiesterase in pharmaceutical screening to identify compounds for treatment of neoplasia 1 1998
* 6130053 Method for selecting compounds for inhibition of neoplastic lesions 12 1999
6177471 Method for treating patients with acne by administering a CGMP-specific PDE inhibitor 33 1999
6500610 Methods for identifying compounds for inhibiting of neoplastic lesions, and pharmaceutical compositions containing such compounds 7 1999
6555547 Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative 3 2000
6569638 Method for screening compounds for the treatment of neoplasia 0 2000
* 2003/0190,686 Methods for identifying compounds for inhibition of neoplastic lesions, and pharmacetical compositions containing such compounds 1 2002
 
Vertexd Pharmaceuticals Incorporated (1)
8329662 Prodrug of an ICE inhibitor 2 2011
 
SMITHKLINE BEECHAM CORPORATION (1)
6787651 Substituted indoles, pharmaceutical compounds containing such indoles and their use as PPAR-.gamma. binding agents 17 2001
 
Cytovia, Inc. (12)
6184210 Dipeptide apoptosis inhibitors and the use thereof 29 1999
* 6153591 Dipeptide caspase inhibitors and the use thereof 39 1999
6620782 Substituted 2-aminobenzamide caspase inhibitors and the use thereof 7 2000
6355618 Caspase inhibitors and the use thereof 13 2000
6495522 Substituted alpha-hydroxy acid caspase inhibitors and the use thereof 11 2000
6596693 Dipeptide apoptosis inhibitors and the thereof 3 2000
6566338 Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death 8 2000
6716818 Caspase inhibitors and the use thereof 8 2001
6949516 Dipeptide apoptosis inhibitors and the use thereof 1 2003
* 2003/0181,391 Dipeptide apoptosis inhibitors and the use thereof 0 2003
* 2003/0181,388 Substituted 2-aminobenzamide caspase inhibitors and the use thereof 2 2003
* 2004/0116,355 Caspase inhibitors and the use thereof 3 2003
 
IDUN PHARMACEUTICALS, INC. (4)
6515173 Inhibitors of the ICE/ced-3 family of cysteine proteases 1 2000
* 2003/0119,748 C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ice/ced-3 family of cysteine proteases 3 2002
* 2005/0065,093 Inhibitors of the ICE/ced-3 family of cysteine proteases 0 2004
* 2006/0084,613 Inhibitors of the ICE/ced-3 family of cysteine proteases 0 2005
* Cited By Examiner