Process for preparing polynucleotides on a solid support in a tightly packed bed

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United States of America Patent

PATENT NO 5869643
SERIAL NO

08358556

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Abstract

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The present invention relates to a process for preparing polynucleotides on a solid support in a reactor in the form of a column through which solutions of reagents and/or solvents are circulated, wherein the solid phase constituting said solid support is immobilized in said reactor, and said solutions migrate in the column and through the solid phase according to a frontal progression, such that the successive solutions from each step of a synthesis cycle do not mix at all, or very little. The subject of the present invention is also a reactor consisting of a column completely filled with particles of porous materials constituting the solid support, and a synthesis device including such a reactor.

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Patent Owner(s)

Patent OwnerAddress
SIGMA-ALDRICH CO3050 SPRUCE STREET ST LOUIS MO 63103

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chatelain, Francedillaois Paris, FR 4 20
Kumarev, Viktor Villemonble, FR 6 25

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