Liquid immunoglobulin formulations
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United States of America Patent
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Feb 16, 1999
Grant Date -
N/A
app pub date -
Mar 7, 1997
filing date -
Sep 8, 1994
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Abstract
Immunoglobulin preparations, particularly liquid preparations of immunogllin G for intravenous infusion, are stabilized against dimer formation by the addition of one or more amphiphilic stabilizers. Preferred amphiphilic stabilizers are nicotinic acid derivatives, particularly nicotinamide, and naturally-occurring .alpha.-amino acids having a lipophilic side chain, for example phenylalanine, proline, leucine and isoleucine.
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