Boronic compound complexing reagents and highly stable complexes

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United States of America Patent

PATENT NO 5872224
SERIAL NO

08956194

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Boron compound complexing reagents, boron compound complexes, and methods of synthesizing these reagents and complexes are disclosed. These reagents and complexes include those shown in General Formula CIV, and General Formula CVI. In one embodiment, the reagent of General Formula CIV may be used to form a complex with a boron compound, such as a complex shown in General Formula CVI. ##STR1## In one embodiment, group Z comprises a spacer selected from a saturated or unsaturated chain of up to about 6 carbon equivalents in length, an unbranched saturated or unsaturated chain of from about 6 to 18 carbon equivalents in length with at least one of intermediate amide and disulfide moieties, and a polyethylene glycol chain of from about 3 to 12 carbon equivalents in length; group R.sub.3 is selected from one of an H, an alkyl, and a methylene or ethylene moiety with an electronegative substituent; and BAS and BAS* are biologically active species.

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Patent Owner(s)

  • CAMBREX BIO SCIENCE ROCKLAND, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kaiser, Robert J Bothell, WA 24 291
Lund, Kevin P Lynnwood, WA 19 90
Stolowitz, Mark L Woodinville, WA 48 762

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