Methods of screening for non-hormone compounds which effect modulation of polypeptide translation
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United States of America Patent
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Feb 23, 1999
Grant Date -
N/A
app pub date -
Aug 22, 1994
filing date -
Aug 22, 1994
priority date (Note) -
Expired
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Abstract
Method for screening for a non-hormone agent potentially useful to treat a hormone disorder. The method involves contacting a potential agent with a system containing a cellular component and a translation factor. The component and factor interact with one another in an intact normal cell in a manner responsive to the hormone to cause a modulation of translation in the cell. The method involves determining whether the agent causes a modulation of translation by the component and the factor analogous to that which occurs in intact cells in response to the hormone.
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