Bis-anthracyclines with high activity against doxorubicin resistant tumors
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United States of America Patent
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Feb 23, 1999
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N/A
app pub date -
Mar 21, 1997
filing date -
Mar 22, 1996
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Expired
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Abstract
The present invention discloses new and novel bisanthracyclines linked through the saccharide portions. These compounds show high activity against two clinically relevant mechanisms of resistance. A novel approach of the invention produces compounds that are as active or more so than the parent compounds. Furthermore, the inventor's discovery is also for the design of effective DNA-binding bisanthracyclines as well as anthracyclines mixed with other intercalators and groove binders.
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