Microcapsule containing amorphous water-soluble 2-piperazinone-1-acetic acid compound
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United States of America Patent
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Mar 2, 1999
Issued Date -
N/A
app pub date -
Sep 30, 1996
filing date -
Sep 28, 1995
priority date (Note) -
Expired
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Abstract
A microcapsule contains a pharmaceutically effective amorphous water-soluble 2-piperazinone-1-acetic acid compound or salt thereof and a polymer binder and a method of preparing said microcapsule. The microcapsule is produced by dispersing in an aqueous phase a dispersion of the amorphous water-soluble 2-piperazinone-1-acetic acid compound or salt thereof in a solution of a polymer in an organic solvent to give an s/o/w type emulsion and subjecting the emulsion to in-water drying. The sustained-release microcapsule entraps 2-piperazinone-1-acetic acid compound or the salt thereof, as a drug, in high concentration, and in reducing the initial release of the drug, thereby reducing undesirable side effects of the drug.
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