APP770 mutant in alzheimer's disease
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United States of America Patent
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Mar 2, 1999
Grant Date -
N/A
app pub date -
Jan 21, 1992
filing date -
Jan 21, 1991
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Abstract
Model systems of Alzheimer's disease comprise a DNA sequence encoding an amyloid precursor protein (APP) isoform or fragment that has an amino acid substitution. The substituted amino acid may be other than valine at the amino acid position corresponding to amino acid residue position 717 of APP770. Methods of determining genetic predisposition to Alzheimer's disease are also disclosed.
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