Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
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United States of America Patent
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Mar 9, 1999
Issued Date -
N/A
app pub date -
Apr 18, 1997
filing date -
Jul 27, 1993
priority date (Note) -
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Abstract
Sustained release pharmaceutical formulations containing morphine, or a pharmaceutically acceptable salt thereof, as active ingredient, suitable for administration on a once daily basis, are disclosed. In a first aspect, an orally administrable sustained release unit dosage form gives a peak plasma level at 1.0 to 6 hours after administration. In a second aspect, the formulation provides a W.sub.50 for the M-6-G metabolite for morphine of between 4 and 12 hours. A third aspect concerns the pharmaceutical unit dosage form obtained by compressing multiparticulates comprising a pharmaceutically active substance in a matrix of hydrophobic fusible material having a melting point of from 35.degree. to 150.degree. C.
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